犬冠状动脉内植入过大支架──一种新的再狭窄模型

The implantation of oversized stent in canine coronary artery: A new animal model of restenosis

为建立一种新的再狭窄模型，初步探讨再狭窄的形成机理。在16只犬冠状动脉内植入过大的钽丝支架，28d后用常规HE、免疫组化和原位杂交方法作组织学分析。结果：新生内膜厚度与血管壁损伤程度呈正相关，新生内膜中含有大量血管平滑肌细胞及胶原纤维，血小板源生长因子主要由内皮细胞分泌但其受体主要分布于新生血管平滑肌细胞。提示：犬冠状动脉内植入过大钽丝支架可作为一种新的动物模型，并为临床研究提供依据。

To develop a new animal model of restenosis oversized tantalum coils were deli vered into coronary arteries of 16 dogs. At 28 days after implantation, the target vessels were har vested and studied with HE staining, immunohistochemistry and in situ hybridization. The neointi mal thickness was related to the vascular injury score. A great deal of smooth muscle cells and col lagen were found in the neointiml. The platelet-derived growth factor-B was secreted from the en dothelial cells primarily but its receptor was located in the proliferative smooth muscle cells. It suggests that implantation of oversized stent in canine coronary artery can create a new animal model of restenosis. The mechanism of restenosis and the relation of oncogenes to restenosis were discussed.