摘要
本文应用胰岛累、胰升血糖素和生长抑累抗血清,通过免疫组化染色对STZ诱导的糖尿病大鼠(I对照组)以及用小磺酸对其进行防治(Ⅱ防治组和Ⅲ治疗组)后胰岛的病理形态进行观察。结果:Ⅱ和Ⅲ组较Ⅰ组胰岛B细胞变性坏死程度明显减轻,且B细胞表达胰岛素呈阳性的胰岛分别占44.6仍和34.9%,均较Ⅰ组23.3的增高,Ⅱ和Ⅰ级之间行显著差异(P<0.05).三个组均见部分胰岛表达升血糖素的A细胞发生明显增生。胰岛D细胞未见病理改变。我们的结果提示STZ对胰岛B细胞具有直接的损伤作用;A细胞的增生可能与STZ有关,并参与了升高血糖效应。牛磺酸对STZ造成胰岛B细胞的损伤具有比较明显修复作用。
Pathological morphology of pancreatic islets in streptozotocin induced rats( I ,control group) and taurine prevention and treatment diabetic rats(include Ⅱ,prevention and treatment group, Ⅲ ,treatment group)was investigated by immunohistochemical method using insulin,glucogan and somatostatin antisera.The results showed that the degree of degeneration and necrosis weakened obviously for the pancreatic B-cells in Ⅱ and Ⅲ compared with I ,the pancreatic islets of positive staining for insulin antiserum were 44.6% and 34.9% respectively,which was higher than that(23.3%)in I ,and signoficant difference between Ⅱ andⅠ (P<0.05)was observed.Among all the three groups,hyperl- asia was seen in the panereatic A-cells,but no pathologic change demostrated in the pancrestic D - cells.The results indicate that streptozotocin can cause the direct damage to the B - cells and taurine has repairing effect against the damage of the pancreatic D-cells by streptozotocin.Hyperplasia of the A - cells my be related to administered streptozotocin and involved in hyperglycemia in Wistar rats.
出处
《重庆医科大学学报》
CAS
CSCD
1997年第3期203-206,共4页
Journal of Chongqing Medical University
基金
四川省卫生厅资助