儿童慢性淋巴细胞性甲状腺炎的临床特点及诊断

Chronic lymphoctic throiditis in children:clinicalcharacteristics and diagnosis

对５４例儿童慢性淋巴细胞性甲状腺炎（ＣＬＴ）进行了回顾性分析。结果：弥慢性甲状腺肿大５４例，甲状腺抗球蛋白抗体（ＴＧＡ）阳性４６例，甲状腺抗微粒体抗体（ＭＣＡ）阳性４８例，甲状腺功能正常４３例，甲状腮功能亢进（甲亢）１例，甲状腺功能减退（甲减）１０例。儿童ＣＬＴ的临床表现和实验室结果不如成人典型。对不能用其它原因解释的甲状脏肿大或甲状腺功能减退，同时具有甲状腺自身抗体增高或甲状腺细针抽吸细胞学检查（ＦＮＡＤ）呈ＣＬＴ细胞像者应考虑ＣＬＴ的诊断。

Fifty - four children with chronic lymphocytic thyroiditis (CLT) were reviewed retrospectivety.All patients had clinical manifestation of diffused goiter and among them 45 patients were with positive antithyroglobulin antibody (TGA) and 48 patients were positive antimicrosomal antibody (MCA). The laboratory tests demonstrated that 43 cases were entyroid, 1 case hyperthyroidism and 10 cases hypothyroidism. The clinical features and laboratory results of CLT in children are not as typical as those in adults. For any child with goiter or hypothyroidism, TGA/MCA positive or with characteristic cytological features in fine needle aspirotion biopsy (FNAB) the diagnosis of CLT should be considered.