口服利福平海藻酸钠微球的制备

Preparation of Rifampicin-Sodium Alginate Microspheres for Oral Administration

目的研制口服利福平海藻酸钠微球。方法采用静电液滴法制备利福平海藻酸钠微球,测定粒径大小、包封率、载药量及其影响因素,考察微球的体外释放特点。结果微球球形圆整,分散性好,平均粒径70.2μm,包封率83.5%,载药量17.1%,在模拟肠液中的释放呈快慢相,时间长而药物释放完全。结论以海藻酸钠、硬脂酸为材料,用静电液滴法制备利福平微球,球径小、包封率高、释药时间长,工艺简便。

Objective To prepare rifampicin -sodium alginate microspheres for oral administration. Methods The method of electrostatic drop generation was used to produce rifampicin-sodium alginate microspheres . The physical characteristics and release profile of the microspheres were examined. Results The microspheres were well spherically shaped and had good dispersity . The mean diameter, entrapment efficiency and loading efficiency of the microspheres were 70.2 ~m, 83.5 % and 17. 1% respectively. Prolonged and complate release of the drug from the microspheres was demonstrated in a simulated intestinal fluid. Conclusion The microspheres prepared with the method showed short sphere diameter ,high entrapment efficiency and long drug release time , and the technology for the preparation was handy.