乌司他丁对脓毒血症患者细胞因子的影响

Influence of Ulinastatin on cytokines of patients with sepsis

目的探讨乌司他丁对脓毒血症患者细胞因子的影响。方法采用前瞻对照研究将84例脓毒血症患者随机分为对照组和治疗组,其中对照组40例,治疗组44例,两组均行常规抗感染和病因治疗。治疗组用乌司他丁20万U溶于20ml生理盐水中静脉注射,每12h一次,连续7天;对照组则予以等量生理盐水作为安慰对照。分别于不同时相(静脉注射UTI前、注射后72h和1周)测试血清肿瘤坏死因子-α(TNF-α)、IL-1、IL-6、IL-8和IL-10水平。结果与对照组相比,治疗组应用乌司他丁后不同时相点的TNF-α、IL-1、IL-6、IL-8均明显降低(P<0.01、P<0.05、P<0.05、P<0.05),而IL-10显著升高(P<0.05)。结论乌司他丁可降低脓毒血症患者TNF-α、IL-1、IL-6和IL-8的水平,而提高IL-10水平,从而达到保护器官的作用。

Objective To evaluate the influence of Ulinastatin on cytokines of patients with sepsis. Methods All 84 / patients were divided into contrast group（40 patients） and treatment group（44 patients） randomly. Therapy with antibiotics and original cause care were same for all patients.UTI 0.2MU for patients in treatment group in vein per 12hrs for 7 days, while in contrast group with physiological saline.Measure cytokines （TNF-α,IL-1,IL-6,IL-8 and IL-10） levels at different times（before inject UTI,after 72hrs and after one week）. Results Levels of cytokines （TNF-α,IL-1,IL-6, IL-8 and IL-10） at different times in treatment group were lower than that in contrast group （P〈0.01, P〈0.05, P〈0.05, P〈0.05）. While IL-10 were increased （P〈0.05）. Conclusion UTI protect septic patients organs.