结缔组织病患者肺部损害54例临床分析

Clinical analyses on lung lesions in patients with connective tissue diseases

我们比较分析54例七种常见结缔组织病（CTD）患者肺部损害的临床表现及实验室检查结果，为达到早期治疗该类疾病的目的。资料分析采用x2检验。结果：患者咳嗽（占55．6％）、咯痰（占46.3％）、发热（占42.6％）、血沉（占83．7％）、胸部X线（占68．5％）、肺CT扫描（占61．1％）、肺功能（占33．3％）等指标，在七种疾病之间比较无显著性差异；乳酸脱氢酶（LDH）（占51．9％）和抗核抗体（ANA）（占53．7％）两项指标，在七种疾病之间比较有显著性差异，以系统性红斑狼疮、皮肌炎和进行性系统性硬化症较为多见。结论：肺功能检测可作为CTD类疾病肺部受损的早期发现指标之一，LDH升高可提示CTD患者肺部累及，胸部X线改变无特异性。

To treat these seven kinds of common connective tissue diseases (CTD) early,the clinical manifestationsand data of laboratory tests of lung lesions in 54 patients with CTD were comparatively studied. Data were analyzed withX2 test. The resuls showed that there was no statistically significant difference in these criteria of cough (55. 6% ),expectoration (46. 3 % ), fever (42. 6 % ), erythrocyte sedimentation rate (ESR) (83' 7% ), chest X-ray (68' 5%), computer tomography (CT) pulmoscanning (61. 1 % )and pulmonary function (33. 3%)in seven kinds of diseases. There was statistically significant difference in these two criteria of lactodehydrogenase (LDH) (5l. 9%)and antinuclear antibody(ANA)(53. 7 % )in seven kinds of diseaese with more common in three diseases of systemic lupus erythematosus (SLE),dermatomyositis (DM )and progressive systemic sclerosis (PSS). Pulmonary function test was regarded as one of the criteriain the early finding of lung lesion in CTD. The increase of LDH was indicative of the lung lesion in CTD. The chest X-rayfindings were not specific.