手术创伤对新生儿内分泌和代谢影响的研究

The Endocrine and Metabolic Response to Surgical Injury in the Neonate

对15例行外科手术的新生儿进行内分泌及代谢方面的研究。发现术后所有患儿均有皮质醇和生长激素的升高，血清前白蛋白和白蛋白下降，表明机体处于分解代谢状态。前白蛋白可以作为监测应激反应严重程度及营养支持是否有效的指标。

In order to know more about effects of surgery on the endocrine and metabolism, the levels ofserum insulin,cortisol and growth hormone were measured in addition to blood glucose,albumin (Alb) and prealbu-min (PA) in 15 neonates undergoing surgery. Elevation of serum cortisol and growth hormone was found immedi-ate after surgery,and the elevation disappeared within 48 hour after surgery。Both Alb and PA concerntrations inserum decreased postoperatively. These data denoted catabolic state. However,serial serum PA markers were supe- rior to Alb markers as to monitor the protein response in neonates following surgery.