卵巢癌1∶1病例-对照研究

1∶1 pair matched case control study in ovarian carcinoma

目的：探索卵巢上皮癌（卵巢癌）发生的有关危险因素。方法：用１∶１配比病例对照研究方法，调查蚌埠市４所医院１０８对病例和对照的生育史、疾病史、避孕史、家庭肿瘤史和饮食因素等，对资料进行单因素和条件Ｌｏｇｉｓｔｉｃ回归模型的多因素分析。结果：不孕和孕次较少（ＯＲ＝０．２４，Ｐ＜０．０１）、动物脂肪摄入量多（ＯＲ＝４．２５，Ｐ＜０．０１）、肿瘤家族史（ＯＲ＝３．１８，Ｐ＜０．０１，与卵巢癌发生有显著联系。结论：不孕和孕次较少、动物脂肪摄入量多和有肿瘤家族史是卵巢癌发生的主要危险因素。

Objective:To study the risk factors associated with ovarian carcinoma.Methods:1∶1 pair matched case control study was carried out in Bengbu city.A total of 101 pairs of cases and controls from four hospitals were interviewed regarding their health history,menarche history,fertility,lifestyle,and family history of cancer.The data were fitted in conditional logistic regression analysis.Results:It showed that the nulliparity or low parity(OR=0.24, P <0.01),high fat diet(OR=4.25, P <0.01) and family history of cancer(OR=3.18, P <0.01) were closely associated with ovarian carcinoma.Conclusions:The nulliparity or low parity,high fat diet and family history of cancer were major risk factors of ovarian carcinoma.