上皮生长因子对深Ⅱ°创面愈合影响的实验研究

The Influence of EGF to the Deep Second Degree Burn Wounds

模型大白鼠深Ⅱ°烫伤创面，以基质为对照组及含重组上皮生长因子（含10μg／grhEGF）为用药组，创面换药。探讨EGF对烧伤创面的愈合影响．结果用药组创面愈合时间早于对照组，创面愈合后上皮角质细胞及上皮乳头增多，两组新生皮与皮下结缔组织结合程度亦存在明显差异．提示EGF具有明显促上皮生长、加速创面愈合作用．

The second degree burn wounds of the model white mice covered seperately with cream containing sole matrix and cream containing rhEGF at a desage of 10μg/g, and the healing effect of the two groups (control group and rhEGF group) were studied.In this study, we found that in the rhEGF group there was a relatively shorter healing time than that the control group.After the wounds had healed, we found that the epithelical keratinocytes and epithelial papillae increased in the rhEGF group.There were significant difference in the conective strength between the new skin and the connective tissue underneath in both groups. These changes imply that EGF has the efiect of promoting epithelium growth,and that of accelerating wound heqling.