摘要
目的:研究柑桔果实中提取的柠檬苦素对实验动物模型的抗炎镇痛作用。方法:采用小鼠福尔马林实验及扭体实验观察柠檬苦素的镇痛作用;通过小鼠耳廓肿胀模型和角叉菜胶致大鼠足肿胀模型观察柠檬苦素的抗炎作用。结果:柑桔果实中提取的柠檬苦素能显著提高小鼠福尔马林实验中的痛域;减少扭体次数;显著抑制二甲苯致小鼠耳廓肿胀和角叉菜胶致大鼠足肿胀程度。结论:柑桔果实中提取的柠檬苦素对本实验中的动物模型具有显著的抗炎及镇痛作用。
Objective： To study the anti- inflammation and analgesic effects of citrus frutis limonoids. Methods： The analgesic effects of limonoids were assayed by formaldehyde test and writhing test in mice. The anti-inflammation effects of limonoids were tested by both mouse＇s ears edemata caused by dimethylbenzene and rat＇s meta tarsus edemata caused by para-carrageenan. Result： Limonoids from citrus frutis can inhibit the nociceptive response by formaldehyde, reduce the writhing number, and obviously inhibit edemata of the mouse＇s ears by dimethyienzene and of the rat＇s tarsus caused by para-carrageenin. Conclusions： Limonoids from citrus frutis have potent anti-inflamation and analgesic effect.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2007年第11期515-518,共4页
Food Science
基金
广东省自然科学基金项目(04002072)
关键词
柠檬苦素
抗炎
镇痛
limonin
anti-inflamation
analgesic
