黑米花色苷提取物对果糖喂养大鼠胰岛素抵抗及血脂的影响

Effects of Black Rice Anthocyanin-Rich Extract on Insulin Resistance Prevention and Hyperlipidemia Amelioration in Fructose-Fed Rats

目的:研究黑米花色苷提取物对果糖喂养大鼠胰岛素敏感性及血脂的影响。方法:采用高果糖饲料诱导建立大鼠胰岛素抵抗模型,饲料中分别添加黑米花色苷提取物(5g/kg饲料)和吡格列酮(270mg/kg饲料),空白对照组动物饲以正常饲料。结果:膳食干预并没有对大鼠体重和摄食量造成显著影响。黑米花色苷提取物能够有效地预防和改善果糖诱导的胰岛素抵抗;和模型对照组相比,花色苷提取物和吡格列酮均能显著地降低血浆游离脂肪酸和甘油三酯含量并提高高密度脂蛋白含量。

Objective： To evaluate the effects of anthocyanin-rich extract from black rice on insulin resistance and hyperlipidemia amelioration in the fructose-fed rats test. Method： A total of 60 rats were randomly divided into five groups to receive 8-week diets as follows： regular diet; high-fructose diet; high-fructose diet preventively supplemented with 5 g of extract/kg diet; and the other two groups firstly received high-fructose diet for 4 weeks, then treated with 5 g of extract/kg diet or 270 mg of pioglitazone/ kg diet for the last 4 weeks. ResUlts： The anthocyanin-rich extract prevents the development of fructose-induced insulin resistance, and significantly ameliorates the hyperlipidemia and insulin resistance in fructose-fed rats, but the extract fails to reverse the fructose-induced hyperinsulinemia as pioglitazone does.