麦草粉与绿茶对亚硝化鱼露致微核率增高的抑制作用

THE INHIBITORY EFFECTS OF BARLEY SEEDING FOOD AND GREEN TEA ON THE INCREASE OF THE MICRONUCLEUS FREQUENCY OF BONE MARROW CELLS INDUCED BY NITROSATED FISH SAUCE

应用小鼠骨髓嗜多染红细胞（ＰＣＥ）微核试验方法，研究麦草粉与绿茶对胃癌高发区鱼露经亚硝化后致突变的抑制作用。结果表明，２０％麦草粉、１０％绿茶可降低亚硝化鱼露所致的小鼠微核率增高的作用（Ｐ＜０．０１）。将按成分换算后相当于０．０２％ＶＣ的２０％麦草粉干预组和０．００２％ＶＣ的１０％绿茶干预组与０．１％ＶＣ干预对照组比较，微核出现率没有显著差异（Ｐ＞０．０５）。提示麦草粉、绿茶的抑制作用尚与ＶＣ外的其他活性成分有关。两者可能有希望成为喜食鱼露的胃癌高发区居民安全无毒又易被接受的天然保护食物。

The inhibitory effects of barley seeding food and green tea on mutagenicity induced by nitrosated fish sauce from a high-risk area for gastric cancer were studied with the micronucleus test on PCEs in mouse bone marrow.The results showed that 20% barley seeding food or 10% green tea could reduce the micronucleus frequency induced by nitrosated fish sauce (P<0.01).There was no significant difference between either 20% barley seeding food interventive group (containing 0.02% Vitamin C)or 10% green tea interventive group (containing 0.002% Vitamin C) and 0.1% Vitamin C interventive control group (P>0.05).These suggested that other active compositions besides Vitamin C in barley seeding food or green tea accounted for their inhibitory effects.They might be used as easily-acceptable,safe,natural,protective food for people prefering fish sauce in high-risk area for gastric cancer.