摘要
甲醛（ＦＡ）在多种体外诱变测试中呈阳性，啮齿动物吸入甲醛蒸气后可引起鼻腔鳞状上皮细胞癌（１，２），接触人群的肿瘤发病率有升高趋势（３，５），因此对甲醛接触人群进行简单有效的遗传毒理学的生物学监测是十分必要的。本次研究微核测试的结果证实：８０名平均工龄１２年的甲醛接触者的外周血淋巴细胞微核细胞率较对照组有极显著的增加（Ｐ＜０．０１）．接触组吸烟人群较对照组吸烟人群的微核细胞率有极明显的增高（Ｐ＜０．０１），接触组非吸烟人群较对照组非吸烟人群的微核细胞率有明显的增高（Ｐ＜０．０５）。因此我们认为甲醛是一种染色体断裂剂及非整倍体诱变剂。我国现行车间空气中甲醛的最高容许浓度为１９７９年颁布国家标准３ｍｇ／ｍ３，尽管空气中甲醛浓度低于国家标准，但接触人群微核细胞率及ＣＡ率仍有极显著性的增加，说明我国现行的甲醛浓度标准是不安全的。外周血淋巴细胞微核测试法取材方便，操作方法简便、快速、敏感，针对甲醛接触人群是一种值得推广的遗传毒理学的生物学监测方法。
In this study,micronucleated cell(MNC) in human peripheral lymphocyte was proposed a biomarker of the cytogenetical damage in healthy workers occupational exposed to FA.The average atmospheric concentration of FA in the working place was 2.51mg/m 3 that is lower than the maximum allowable concentration (MAC).Significant increased frequencies of MNC were found in the lymphocytes of the workers exposed to FA.The group of exposure compared with the group of control as follows:smokers MNC(11.55‰ v 6.25‰,P<0.01) ,nonsmokers MNC(10.95‰ v 7.47‰,P<0.05) and total average MNC(11.26‰ v 7.00‰,P<0.05).The results clearly indicated that low occupational exposure to formaldehyde may increase the frequency of the MNC in the human lymphocyte.
出处
《癌变．畸变．突变》
CAS
CSCD
1997年第2期123-125,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
甲醛
微核
淋巴细胞
工业毒理
Formaldehyde
Micronuclei
Population
Lymphocyte
