长骨骨折及髋膝关节置换并发脂肪栓塞综合征的相关因素分析(英文)

Analysis of factors related to long bone fracture and hip-knee joint replacement accompanied with fat embolism syndrome

学术背景:脂肪栓塞综合征是骨科临床上的常见严重并发症。多发生在长骨骨折和髋膝关节置换术后,但是其病因、发病机制仍未明确。目的:总结长骨骨折及髋膝关节置换术并发脂肪栓塞综合征的发病影响因素、发病机制和诊治方法。检索策略:由该论文的研究人员检索Pubmed数据库,检索词"fatembolism syndrome,pathogenesis,treatment,prevention,diagnosis",并限定文章语言种类为English。共检索到55篇文献。同时检索上海交大医学情报网络,检索词"脂肪栓塞综合征,发病机制,治疗,预防,诊断",限定文章语言种类为中文。纳入标准:能反映脂肪栓塞综合征诊断和治疗及发病机制的文章。排除标准:重复性研究。文献评价:纳入的38篇文献均是关于脂肪栓塞综合征的诊断和治疗及发病机制方面的文章,其中6篇为综述,其余为临床或基础研究。资料综合:①脂肪栓塞综合征的影响发病因素包括创伤因素、手术因素和其他因素。②脂肪栓塞综合征的发病机制相关理论有机械阻塞理论、生物化学理论、凝结理论和炎症反应理论。③脂肪栓塞综合征的治疗包括呼吸支持、糖皮质激素应用、保护脑功能、药物治疗、抗休克治疗等。结论:对骨折和关节置换术后并发脂肪栓塞综合征进行研究可为该综合征的诊断和防治提供依据。

BACKGROUND： Fat embolism syndrome is a commonly seen severe complication in the field of opthopaedics in clinic. It frequently occurs after long bone fracture and hip-knee joint replacement. However, its etiological factors and pathogenesis are not identified. OBJECTTVE： To sum up the onset influencing factors, pathogenesis and therapeutic methods of long bone fracture and hip-knee joint replacement accompanied with fat embolism syndrome. RETRIEVE STRATEGY： Using the terms ＂fat embolism syndrome, pathogenesis, treatment, prevention, diagnosis＂, we retrieved PubMed database to identify studies published in the English language. Fifty-five literatures were searched. Meanwhile, we searched the medical information network of Shanghai Jiao Tong University with the same terms in the Chinese language. Inclusive criteria： studies, which can reflect the diagnosis and treatment as well as pathogenesis of fat embolism syndrome. Exclusive criteria： repetitive studies. LITERATURE EVALUATION： The involved 38 literatures are all about the diagnosis and treatment as well as pathogenesis of fat embolism syndrome, among which, 6 were review and the others were clinical or basic studies. DATA SYNTHESIS ： ① The influencing factors of fat embolism syndrome included trauma factor, operation factor and other factors. ②The pathogenesis of fat embolism syndrome involved mechanical obstruction theory, biochemical theory, condensation theory and inflammatory reaction theory. ③ The treatments of fat embolism syndrome include respiration supporting, glucocorticoid application, protecting brain function, drug treatment, heat shock treatment and so on. CONCLUSION： Study on bone fracture and joint replacement accompanied with fat embolism syndrome can provide evidence for the diagnosis and treatment of this syndrome.