重庆地区儿童乙型肝炎病毒感染状况分析

Analysis of the infection status of hepatitis B virus in Chongqing children

目的:初步了解重庆地区儿童乙型肝炎病毒的感染状况。方法:对来重庆医科大学儿童医院就诊的8060例儿童用ELISA方法检测乙肝6项。结果:HBsAg阳性率为4.44%,抗-HBs阳性率为46.56%,两对半全阴性儿童3795人,占47.08%;大三阳259人,占3.21%;小三阳80人,占0.99%。Pre-S1阳性率为3.51%。结论:来我院检查的8060例儿童,乙肝病毒感染率为4.44%,低于我国成人乙肝病毒携带率;Pre-S1与HBeAg有一定相关性,能在一定程度上反映乙肝病毒增殖情况和传染性。

Objective：To investigate infection status of hepatitis B virus in ChongQing children. Method：We detected the HBV serology markers（HBVM） by ELISA in 8060 children in Children＇s Hospital of Chongqing Medical University. Results：HBsAg positive rate was 4.44%,anti-HBs positive rate 46.56%. 3795 cases were negative in HBVM（47.08%）;259 cases were positive in HBsAg,HBeAg and anti-HBc（3.21%）;80 cases were positive in HBsAg, anti-HBe, anti-HBc （0.99%）,and Pre-S1 positive rate was 3.51%. Conclusion：Among the 8060 children who came to our hospital,the infection rate of HBV is 4.44%,lower than in the adults. Pre-S1 is related with HBeAg,and it can reflect the status of HBV multiplication and infectivity to some extent.