盐酸丁咯地尔对实验SD大鼠坐骨神经损害恢复的影响

Study on recovery action of Buflomedil Hydrochloride to peripheral nerve crush lesion in rats

目的:观察盐酸丁咯地尔对周围神经损害后恢复的影响。方法:以SD大鼠坐骨神经建立周围神经损害动物模型,以坐骨神经传导速度、坐骨神经干病理切片(光镜、电镜)为观察指标,考察盐酸丁咯地尔对周围神经损害后恢复的影响。结果:盐酸丁咯地尔组给药4周后能显著改善大鼠坐骨神经损害。结论:盐酸丁咯地尔对周围神经损害有确切的修复作用。

Objective：study on recovery action of Buflomedil Hydrochloride to peripheral nerve crush lesion in rats. Methods： Sciatic nerve crush lesion model were established in rats,The conduction velocity of sciatic nerve and the morphological changes were observed by light and electron. Results：At the end of 4 weeks, Buflomedil Hydrochloride can obviously recover the sciatic crush lesion in rats. Conclusion：Buflomedil Hydrochloride shows recovery effect on the peripheral crush lesion.