摘要
不对称细胞分裂是动物发育过程中用以调控细胞分化的一种进化上保守的基本模式。极性的祖细胞通过不对称分裂产生两个不同命运的子细胞,这一过程涉及细胞命运决定因子的不对称分布、纺锤体的旋转定位等,而这些过程都必须依赖特定细胞极性的存在才能得以正常进行。简要综述了高度保守的蛋白复合物PAR/aPKC在细胞极性建立和维持中的重要作用,以及它如何调控纺锤体定位和命运决定因子不对称分配,并讨论了在该领域的一些新发现和研究进展。
Asymmetric cell division is a fundamental pattern regulating cell differentiation during animal development and is also conserved in evolution. A polarized progenitor gives rise to two daughter cells with different fates through the asymmetric division which involves the asymmetric distribution of cell fate determinants and the orientation of the mitotic spindle. Both processes need the presence of certain cell polarity. In this paper, how PAR/aPKC complex, a highly conserved protein complex, functions in the establishment and maintenance of cell polarities as well as in the regulation of deterninants distribution and mitotic spindle orientation were reviewed, and some recent findings and progresses in this field were also discussed.
出处
《生物技术通讯》
CAS
2007年第6期995-997,共3页
Letters in Biotechnology
基金
国家人事部留学择优基金项目
浙江省自然科学基金项目(Y204183)
