哺乳动物卵泡卵母细胞发生的分子调控

Molecular Regulation of Mammalian Folliculogenesis and Oogenesis

哺乳动物卵泡卵母细胞发生的研究一直是发育生物学研究的重点之一。简要叙述了哺乳动物卵泡卵母细胞发生的一般过程,重点分析了原始生殖细胞向卵母细胞分化过程中gdf9、c-kit、BMP4及TGF家族关键基因的表达调控对卵母细胞发生的影响,以及卵母细胞与颗粒细胞间的相互调节作用,介绍了卵母细胞体外发生的最新研究进展及面临的难题等,为进一步研究原始生殖细胞向卵母细胞分化以及卵泡生长发育的机制提供了理论基础。

Mammalian folliculogenesis and oogenesis research is an important part of the developmental biology. In this paper, the progression of mammalian folliculogenesis and oogenesis, many key genes such as gdfg, c-kit, BMP4 and TGF involved in the cellular differentiation proceeding from primordial germ cells to oocytes, the interrelationship between oocyte and granulose cells within the growing follicles, the advance of mammalian oogenesis in vitro were reviewed. Molecular regulation processes of oogenesis provide a clue to mechanism of mammalian oogenesis from primordial germ cells to ooevtes.