低剂量米非司酮配伍利凡诺在中期妊娠引产的作用

Combining Rivanol with Low-dosage Mifepristone for Induced Abortion of Second Trimester The General Hospital of Taigang

目的观察低剂量米非司酮胶囊在利凡诺中期妊娠引产中的作用。方法选择40例欲行利凡诺羊膜腔内注射法中期引产的孕妇，随机分为两组：实验组和对照组各20例。实验组：于注射前32、20、8小时口服米非司酮胶囊（Ⅱ）20mg、20mg、10mg，共三次，（总量50mg）。对照组：单纯利凡诺羊膜腔注射引产，观察两组引产进程及胎盘滞留、产后出血及宫内残留行清宫术的发生情况。结果实验组腔内注射至产程发动时间、产程发动至胎儿娩出时间均短于对照组，胎盘滞留、产后出血及宫内残留发生率也低于对照组，差异具有统计学意义，治疗过程中无严重副作用发生。结论低剂量米非司酮胶囊配伍利凡诺羊膜腔内注射法中期引产可加速产程，提高完全流产率，从而提高引产质量。

Objective To observe the effects of combining rivanol with low-dosage mifepristone capsules （Ⅱ） on induced abortion of second trimester. Methods： Forty women who were expected to terminate second trimester pregnancy with intraamniotic rivanol were randomized into two groups .The women in mifepristone capsules （ Ⅱ ） group （n=20） were administered 20mg , 20mg , 10mg mifepristone capsules （Ⅱ） three times at 32,20,8 hours before receiving rivanol , and the women in control group （n=20） only receiving rivanol. The process of induction abortion, retained placenta, postpartum hemorrhage and evacuation of the uterine leftover were recorded. Results： For mifepristone capsules （Ⅱ） group, the interval between administration of rivanol and onset of labor and the interval between onset of labor and expulsion of fetus were both shorter compared with control group. The condition of retained placenta, postpartum hemorrhage and uterine leftover were less than control group. （P 〈 0.01） Side-effects associated with mifepristone capsules （Ⅱ） was mild. Conclusion： Low-dosage mifepristone capsules （Ⅱ） used in the rivanol induced abortion of second trimester can accelerate the process of induction abortion and enhance percentage of complete abortion.