摘要
基因芯片技术以高通量、高效率、大规模的独特优势，为心血管外科的各类疾病的研究提供了强有力的系统研究手段。本文着重阐述了基因芯片技术在先天性心脏病研究慢性心衰、心肌保护及心脏移植排斥反应四方面的应用。
出处
《中外医疗》
2007年第20期61-62,共2页
China & Foreign Medical Treatment
参考文献10
-
1[2]Sehl A,Mataki C,Murakami T.A comparison of gene expression in murine cardiac allografts and isografts by means of DNA microarray analysis[J].Transplantation,2001,72:320-329.
-
2[3]Barrans JD,Allen PD,Stamatiou D.Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardio vascular-based Cdna microarray[J].AM J Pathol,2002,160:2035-2043.
-
3[4]Steenman A,Kristian Damas J,Geir Eiken H.Increased gene expression of tumor necrosis factor superfamily ligands in peripheral blood mononuclear cells during chronic heart failure[J].Cardiovasc Res,2002,54:175-182.
-
4[5]Onodya A,Zvara A,Hackler LJ,et al.Effect of classic preconditioning on the gene expression pattern of rat hearts:a DNA microarrays study[J].FEBSLett,2003,11:536(1-3):35-40.
-
5吕青兰,袁灿,张华莉,陈广文,王尧玲,邓恭华,涂自智,肖献忠.用cDNA芯片检测大鼠心肌缺血预适应后基因表达谱的改变[J].中国动脉硬化杂志,2003,11(3):189-193. 被引量：10
-
6[7]Zubakov D,Hoheisel JD,Kluxen FW,et al.Late ischemic preconditioning of the myocardium alters the expression of genes involved in inflammatory response[J].FEBSLett,2003,547(1-3):51-55.
-
7[8]Sergeev P,Dasila R,Lucchinetti E,et al.Trigger-dependent gene expression prpfiles in cardiac preconditioning evidence for distinct genetic programs in ischemic and.anesthetic preconditioning[J].Anesthesiology,2004,100(3):474-488.
-
8[9]Christopher K,Mueller TF,Ma CY.Analysis of the innate and adaptive phases of allograft rejection by cluster analysis of transcriptional profiles[J].J Immunal,2002,169:522-530.
-
9[10]Saiura A,Kohro T,Yamamoto T.Detection of an upregulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gamma by means of DNA microarray[J].Transplantation,2002,73:1480-1486.
-
10伍亚舟,张彦琦,黄明辉,杨梦苏,曾志雄,易东.基因芯片表达数据的标准化策略研究[J].第三军医大学学报,2004,26(7):594-597. 被引量：17
二级参考文献15
-
1[1]Murry CE, Jennings RB, Reimer KA. New insights into potential mechanisms of ischemic preconditioning. Circulation, 1991, 84 (1): 442-445
-
2[2]Deindl E, Schaper W. Gene expression after short periods of coronary occulusion. Mol Cell Biochem, 1998, 186: 43-51
-
3[4]Gross GJ, Kersten JR, Warltier DC. Mechanisms of postischemic contractile dysfunction. Ann Thorac Surg, 1999, 68 (5): 1 898-904
-
4[5]Kohler C, Gahm A, Nona T. Release of adenylate kinase from the mitochondrial intermembrance space during apoptosis. FEBS lett, 1999, 447 (1): 10-12
-
5[6]Nathalie Rosenblatt-velin, Christophe, Montessuit C, Papageorgiou I, Terrand J, Lerich R. Postinfarction heart failure in rats is associated with upregulation of GLUT-1 and downregulation of genes of fatty acid metabolism. Cardiovasc Res, 2001, 52 (3): 407-416
-
6[7]Tonner E, Allan G, Shlreta L, Webster J, Whitelaw CB, Flint DJ. Insulin-like growth factor bindingprotein-5(IGFBP-5) potentially regulates programmed cell death and plasminogen activation in the mammary gland. Adv Exp Med Boil, 2000, 480: 45-53
-
7[8]Paunesku T, Mittal S, Protic M. Proliferating cell nuclear antigen (PCNA): ringmaster of the genomeInt. J Radiat Biol, 2001, 77 (10): 1007-021
-
8[9]Irmgard ST, Johannes R, Johannes R, Jorn-Peter H, Michaela B, Thomas V. The Ca2+-binding proteins S100A8 and S100A9 areencoded by novel injury-regulated genes. J Biol Chem, 2001, 276 (38): 35 818-825
-
9[10]Clare MD, Jean R, Mc Ewan,Adrinao MH. Matrix metalloproteinase and cardiovascular disease. Circ Res, 1995, 77: 863-868
-
10[11]Chen Y, Segarini P, Raoufl F,Bradham D, Leask A. Connective tissue growth factor is secreted though the Goligi and is degraded in the endosome. Exp Cell Res, 2001, 271 (1): 109-117
共引文献25
-
1袁灿,赵震宇,刘瑛,吕青兰,王秋鹏,肖献忠.cDNA微阵列结合聚类分析探讨大鼠心肌缺血-再灌诱导的基因表达谱改变[J].中南大学学报（医学版）,2004,29(3):252-256. 被引量：4
-
2张华莉,袁灿,肖献忠.用生物信息学方法克隆大鼠核不均一核蛋白A2/B1基因[J].中国动脉硬化杂志,2004,12(3):249-253. 被引量：1
-
3伍亚舟,易东,李辉智.基因表达芯片标准化研究进展[J].数理医药学杂志,2005,18(1):60-63. 被引量：3
-
4李晓泓,张露芬,解秸萍.针灸预处理的研究概况与思考[J].中国临床康复,2005,9(25):186-187. 被引量：23
-
5王尧玲,王建设,刘双,袁灿,吕青兰,刘梅冬,刘可,肖献忠.大鼠心肌缺血预适应延迟相的差异蛋白质的分离及鉴定[J].中国动脉硬化杂志,2005,13(4):456-460. 被引量：7
-
6张彦琦,李辉智,易东.基因芯片表达数据分析方法研究进展[J].重庆医学,2005,34(12):1889-1892. 被引量：2
-
7伍亚舟,易东,黄明辉,李辉智.局部均值化方法在基因芯片标准化中的应用研究[J].中国卫生统计,2005,22(6):399-401.
-
8邹定全,常业恬.基因芯片技术在心肌缺血再灌注损伤研究中的应用[J].国外医学（麻醉学与复苏分册）,2005,26(4):228-231.
-
9敖琳,高利宏,胡冉,曾志雄,方志俊,曹佳,杨梦苏.小鼠毒理基因芯片的可靠性验证[J].癌变．畸变．突变,2006,18(2):139-143. 被引量：4
-
10高利宏,敖林,胡冉,刘晋,曹佳.四环素诱导Balb/c小鼠肝脏脂肪代谢相关基因表达谱的变化[J].癌变．畸变．突变,2006,18(2):144-148. 被引量：2
同被引文献13
-
1张雷,吴文成,邵素霞,赵春芳.猴左心室乳头肌工作心肌细胞间闰盘的立体结构与发育[J].电子显微学报,2003,22(6):461-462. 被引量：5
-
2王琦 郭鹞 任东青 等.核电磁脉冲照射对大鼠海马、边缘区超微结构的影响[J].电磁辐射生物学杂志,2002,3(1):95-1130.
-
3方恒虎 曾桂英 任东青 等.不同场强NEMP辐照对大鼠甲状腺超微结构的影响[J].电磁辐射生物学杂志,2004,5(2):121-123.
-
4方恒虎 曾桂英 任东青 等.不同场强NEMP辐照对大鼠垂体超微结构的影响[J].电磁辐射生物学杂志,2004,5(2):115-120.
-
5倪颖 郭鹞 曾桂英 等.NEMP辐照对大鼠肾脏超微结构的影响[J].电磁辐射生物学杂志,2002,3(1):52-56.
-
6任东青.电磁脉冲对大鼠心脏功能、形态的影响及其机理的探讨.西安:第四军医大学,2000:2-16.
-
7Somosy Z, Bognar G,Thuroczy G, et al. Biological responses of tight junction to ionizing radiation and electromagnetic field exposition. Cell Mol Biol, 2002,48(5 ) : 571-575.
-
8李宝丰.NEMP对大鼠心脏功能和结构的影响及其机制探讨.西安:第四军医大学,2006:44-50.
-
9Lindquist S, Craig EA. The heat-shock proteins. Annum Rev Genet, 1998,22(5) :631-677.
-
10Tan FL, Moravec CS, Li JB, et al. The gene expression fingerprint of human heart failure. Proc Natl Acad Sci USA,2002, 99(3) :113872- 11392.
-
1陈婷婷,王刚.基因芯片技术在心脏外科的应用[J].中外医疗,2007,0(21):8-9.
-
2冯义柏.起搏器伴我走四方[J].医疗保健器具（医疗器械版）,2003(4):46-47.
-
3肝脏有没有毒 看四方面[J].养生保健指南,2014,0(11):59-59.
-
4闵庆莲.临床路径在腰椎间盘突出症手术治疗患者中的应用[J].中国实用医药,2010,5(24):191-192. 被引量：10
-
5丁仲如,秦永文.经皮心脏瓣膜置换或修复治疗[J].国外医学（心血管疾病分册）,2005,32(6):324-326. 被引量：1
-
6刘孝东,程惊秋,步宏.基因芯片技术在肾脏生理、病理研究中的应用[J].临床与实验病理学杂志,2004,20(3):361-363.
-
7李文青.“四方四赢”管理新尝试[J].中国卫生产业,2010(1):50-53.
-
8周建大,罗成群,贺全勇,朱颉,陈铁夫,彭浩,李萍,徐阳成.严重烧伤大鼠的内源性保护机制初探[J].实用预防医学,2006,13(2):410-410.
-
9杜大夫间断悬吊提升除皱术享誉四方[J].医学美学美容（美颜志）,2010(2):92-92.
-
10史明,谭勇明,李文恒,杨有猛,徐鸿育,谭家昌.中药洗四方局部熏洗在膝部骨折后期的临床应用[J].实用中西医结合临床,2010,10(1):30-31. 被引量：4
