(E)-2-[2-(6-氯嘧啶-4-基氧基)苯基]-3-甲氧基丙烯酸甲酯的合成工艺改进

Process Improvement on the Synthesis of (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate

以3-(α-甲氧基)亚甲基苯并呋喃-2-(3H)-酮为原料,经3步反应合成了杀菌剂嘧菌酯的重要中间体——(E)-2-[2-(6-氯嘧啶-4-基氧基)苯基]-3-甲氧基丙烯酸甲酯(4),总收率61%。4的结构经NMR表征。

（E） -2 - [ 2- （ 6-chloropyrimidin-4-yloxy ） phenyl ] -3 -methoxyacrylate, a important intermediate of Azoxystrobin, in overall yield of 61% was synthesized by a three-step reaction from 3-（α-methoxy） methylenebenzofurans-2-（3H）- one. The structure was characterized by NMR.