高压氧不同介入时机治疗对颅脑损伤后认知功能及日常活动能力的影响

The influence of congnitive function and activities of daily living by hyperbaricoxygen therapy started at different time in craniocerbral trauma

目的探讨高压氧（hyperbaricoxygen，HBO）不同介入时机治疗对轻中度颅脑损伤后认知功能及日常活动能力的影响。方法将165例轻中度颅脑损伤后认知功能障碍患者随机分为3组．年龄17～53岁．平均年龄32．0岁．分别于伤后7天～1个月（A组）、伤后1～3个月（B组）和伤后3个月（C组）介入高压氧治疗。治疗前后分别采用神经行为认知状态检查表（neurobehavioral cognitive status examination，NCSE）、Barthel指数评定法评定3组患者的认知功能、日常生活活动能力。结果3组患者治疗前后和组间的NCSE和Barthel指数评定法评分比较差异有统计学意义（P〈0．05）．且评分的变化均数比较显示伤后7天～1个月介入高压氧治疗患者的ADL和认知功能恢复显著优于后两组（P〈0．01）。结论早期介入高压氧治疗能明显改善轻中度颅脑损伤后认知功能和日常活动能力。

Objective To study the effect of hyperbaricoxygen （HBO） therapy started different time on congnitive function and activities of daily living （ADL） in patients with mild and moderate craniocerbral trauma. Methods A total of 165 patients with mild and moderate brain injury treated by HBO were randomly divided into threee groups ie, group A（treated after injury 7 days - 1 month） ,group B（treated after injury 1 - 3 month） and group C （treated 3 month later after injury）. The congnitive function and ADL were assessed by NCSE and Barthel＇s ADL before and after treatment. Results After treatment the scores of NCSE and Barthel＇s ADL of three groups increased （P 〈 0.05 ）, and the the scores in Group A 7 days - 1 month were higher than that of the other two groups（P 〈 0.05）. Conclusion The HBO treatment can obviously improve the cognition function and ADL of patients with mild and moderate craniocerebral trauma,especially treating in the early time of injury.