混合性血管内皮瘤1例报告及文献复习

Clinicopathologic Features of 1 Case of Composite Haemangioendothelioma and Relative Literatures Review

目的探讨混合性血管内皮瘤临床病理特点及免疫组化表型。方法对1例混合性血管内皮瘤病理组织学及免疫组化表型中的CD31、CD34、Ⅷ因子、VWF、PCK、Vimentin、EMA进行观察并复习相关文献。结果巨检:送检骨骼肌带筋膜,肌间见31个灰白色结节,直径0.6～2.5cm,切面灰白色鱼肉状。镜检:瘤组织成分复杂,有网状型血管内皮瘤、上皮性血管内皮瘤及梭形细胞血管内皮瘤成分。免疫组化表型为血管来源肿瘤。结论混合性血管内皮瘤属极其罕见低度恶性肿瘤,成分多样。免疫组化表型有助于其诊断分析。

Objective To explore the clinicopathologic features of one case of composite haemangioendothelioma and its immunohistochemistry expression. Methods Monoclonal antibodies including CD31, CD34,Factor VIII, VWF（von Willebrand Factor）, PCK, Vimentin and EMA was used to detect the expression of this case and the relative literatures were reviewed. Results Macroscopy showed that the speciman was a piece of skeletal muscle with fascia. Thirty-one gray nodules whose diameter were 0. 6 to 2. 5 cm could be seen. Microscopy： the neoplasm was consisted of complex admixture of retiform haemangioendothelioma, epithelioid haemangioendothelioma and spindle cell haemangioma. The lesions are positive for vascular markers （CD31, CD34, Factor VIII, VWF ）. Conclusion The composite haemangioendothelioma was a very rare low-grade malignant tumor whose components were diverse. Immunohistochemistry expressions could help us diagnose the tumor.