110例妊娠肝内胆汁瘀积症临床分析

Clinical analysis of 110 cases of intrahepatic cholestasis of pregnancy

妊娠期肝内胆汁瘀积症（intrahepaticcholestasisofpregnancy，简称ICP）对母婴健康均有一定影响，特别是对胎儿影响更大，易发生早产、胎儿宫内窘迫，甚至国产儿死亡和产后出血等不良后果。本文110例ICP，早产占16．38％，低出生体重儿占11．21％，新生儿窒息占9．48％，围产儿死亡率25．86‰。，产后出血占8．18％。因此ICP是围产儿死亡原因急待研究和解决的问题。

Intrahepatic cholestasis of pregnancy(ICP), either the mother or the fatus beingaffected, espcially the latter, is predisposed toprematurity, fetal distress, even to perinata1death or postpartum hemorrhage. From January1991 to July, 1995, 6336 pregnant women wereadmitted to the hospicted for delivery, of those110 cases of ICP occurred with an incidence of 1.74%, 108 cases occurred in primiparae (98.18% ), 2 cases in multiparae (1. 82%) of 110cases of ICP, prematurity occurred in 16. 38%;low birth weight, 11. 2%; fetal distress, 18.10%; neonatal apnea, 9. 48%; perinatalmortality, 25. 86 %; postpartum hemorehage,8.18%.Dexamethasone(DXM) can be administeredto prevent fr0m rspiratary distress syndrome(RDS) for those whose gestation less than 37weeks with fetal movement decreased,abnormality in fetal monitoring, early sympt0rnsbut longer patsogInic procass, and bile acidincreased. Cesarean section is justidied.induction of labor or cesarean section may byindicated for those whose gestation at 37-38weeks and preparation for saving the neonate isalso indicated. After the birth has giren, theagents for contraction can be medicated th inablethe placenta out and to recede postpartumhemorrhage.