含喹诺酮类药物的高分子前药的合成及表征的初步研究

Elementary study on synthesis and characterization of polymer prodrug bonded with quinolones antibiotic

用典型的两步聚氨酯缩合反应，合成了聚氨酯-环丙沙星高分子前药。通过傅立叶变换红外光谱、紫外光谱确定产物为聚氨酯，且药物键合在高分子上，并用紫外．可见分光光度计测定了前药中的药物含量。凝胶渗透色谱分析表明合成的聚氨酯不合大分子的PCL单体。对合成的前药进行了体外降解初步研究，结果表明，在炎症酶——胆固醇酯酶（CE）存在的条件下，药物可以从高分子中控制释放出来。

A polyurethane polymer prodrug bonded with ciprofloxacin was synthesized using a typical two-step polyurethane condensation reaction. The polyurethane structure of the product was confirmed via fourier transform infrared spectroscopy （FTIR）. The UV spectrum showed that the antibiotic had been successfully bonded with the polymer The drug content of the prodrug was detected by UV/VIS spectrometry. Gel permeation chromatography （GPC） spectra of the purified polymer showed that there was no free PCL monomer in the product. In vitro degradation results showed that drug can be control-released from the polymer in the presence of inflammation enzyme-cholesterol enzyme （CE）.