支原体肺炎伴喘息患儿血清IL-13、IgE和嗜酸粒细胞水平分析

Research of IL-13 IgE and EOS in pneumoniae mycoplasma with bronchial asthma children patients

目的探讨支原体肺炎伴哮喘患儿血清IL-13、IgE和嗜酸粒细胞水平及意义。方法采用免疫学方法对70例支原体肺炎患儿（伴喘息患儿36例，不伴喘息患儿34例）的血清IL-13、IgE和外周血嗜酸粒细胞（EOS）水平进行检测，另设30例建康体检者作为继康对照组。结果支原体肺炎患儿的血清IL-13、IgE和外周血嗜酸粒细胞水平明显高于健康对照组；支原体肺伴喘息患儿的血清IL-13、IgE和外周血嗜酸粒细胞水平则又明显高于不伴喘息者，差异均有统计学意义（P〈0．01）。结论IL-13、IgE和嗜酸粒细胞在肺炎支原体导致肺炎哮喘样发作中起重要作用。

Objective To explore signficances of serum IL-13,IgE and EOS in pneumoniae mycoplasma with asthma children patients. Methods IL-13, IgE and EOS in 70 cases of mycoplasma pneumoniae （36 cases with asthnla children patients,34 cases not with asthma children patients）were detected by using immunology method,30 cases normal children as controls. Results The serum IL- 13,IgE and EOS in pneumoniae myeoplasma children patients were sighificantly higher than those of nomal control group, the serum IL-13 ,IgE and EOS in pneumoniae mycoplasma with bronchial asthma children patients were sighificantly higher than those of not with bronchial asthma（P〈0.01）. Conclusion IL-13,IgE and EOS play a role in pneumoniae mycoplasma caused asthma.