致新生儿淋菌性结膜炎菌株抗生素敏感性分析

Antibiotic sensitivity analysis of pathogen strains in neonatal gonococcal conjunctivitis

目的了解引发新生儿淋菌性结膜炎的淋病奈瑟菌的药物敏感性。方法采用K-B纸片扩散法检测淋病奈瑟菌对常用抗生素的药物敏感性，根据2002年美国国家临床实验室标准化委员会（NCCLS）标准判断结果。结果所分离淋病奈瑟菌株对青霉素、四环素、氧氟沙星的敏感性最低，分别为12．5％、15．6％、25．0％；对头孢曲松、头孢他啶、头孢吡肟的敏感性最高，分别为96．9％、96．9％、100．0％。结论引发新生儿淋菌性结膜炎的淋病奈瑟菌耐药现象较为严重，头孢曲松可作为治疗的首选药物，应加强对淋病奈瑟菌的药物敏感性监测，以指导临床合理应用抗生素。

Objective To investigate the antibiotic sensitivity of Neisseria gonorrhoeae in neonatal gonococcal conjunctivitis. Methods Antibiotic sensitivity of Neisseria gonorrhoeae to commonly used drug was tested by Kirby-Bauer disk diffusion method, the results were evaluated based on National Committee for Clinical l,aboratory Standards in 2002. Results Of all the seven antibiotic agents, the lowest sensitivity of Neisseria gonorrhoeae was penicillin, tetracycline and ofloxacin;the percentages of sensitivity were 12.5%, 15.6%, 25.0% respectively. On the other hand, the highest sensitivity of Neisseria gonorrhoeae was ceftriaxone, ceftazidime and cefepime, the percentages of sensitivity were 96.9%, 96. 9% and 100.0%. Conclusion The resistance of Neisseria gonorrhoeae is serious. Ceftriaxone is the first chioce for treating the infection caused by Neisseria gonorrhoeae. Monitoring sensitivity of Neisseria gonorrhoeae to drugs should be strengthened, and it is important to guide the rational use of antibiotics.