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糖蛋白P及其介导的多药耐药及逆转策略 被引量：3

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摘要 多药耐药（MDR）是肿瘤细胞对多种化疗药物产生抗药性的同时，对其它结构不同、靶位不同、作用方式不同的抗肿瘤药物产生交叉耐药性，是最重要、最常见的肿瘤耐药现象，肿瘤细胞对抗癌药物产生耐受性成为肿瘤化学治疗最大障碍之一。近年来研究发现肿瘤的多药耐药主要与一种分子量为170KD的跨膜糖蛋白P（P-gp）有关，由多药耐药基因1（MDR1）编码，本文将讨论有关P-gP及由其介导的肿瘤多药耐药的逆转策略的研究进展。
作者 王永胜（综述） 刘长安（审校）
机构地区 重庆医科大学附属第二医院肝胆外科
出处 《国际检验医学杂志》 CAS 2007年第11期1023-1025,共3页 International Journal of Laboratory Medicine
关键词 P糖蛋白 基因 MDR 肿瘤
分类号 R730.23 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Rosenberg MF, Kamis AB, Callaghan R, et al. Three-dimensional structures of the mammalian muhidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding [ J]. J Biol Chem, 2003, 278(10): 8294-8299.
  • 2Senior AE, Bhagat S. P glycoprotein shows strong catalytic cooperativity between the two nucleotide sites [J]. Biochemistry, 1998, 37(3): 831-836.
  • 3Loo TW, Bartlett MC, Clarke DM. Drug binding in human P- glycoprotein causes conformational changes in both nucleotidebinding domains [J]. J Biol Chem, 2003, 278(3): 1575-1578.
  • 4Loo TW, Clarke DM. Identification of residues within the drugbinding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromo bimane[J]. J Biol Chem, 2000, 275(50): 39272-39278.
  • 5Sharom FJ, Liu R, Qu Q, et al. Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools [J]. Semin Cell Dev Biol, 2001, 12 (3) : 257-265.
  • 6Tsuruoka S, Sugimoto KI, Fujimura A, et al. P glycoproteinmediated drug secretion in mouse proximal tubule perfused in vitro [J]. J AmSoc Nephrol, 2001, 12(1): 177-181.
  • 7Malingre MM, Beijnen JH, Schdlens JH. Oral delivery of taxanes [J]. Invest New Drugs, 2001, 19(2): 155-162.
  • 8Levchenko A, Mehta BM, Niu X, et al. Intercellular transfer of P glycoprotein mediates acquired multidrug resistance in tumor cells [J]. Proc Natl Acad Sci USA, 2005, 102(6): 1933-1938.
  • 9Kang H, Fisher MH, Xu D, et al. Inhibition of MDR1 gene ex pression by chimeric HNA antisense oligonucleotides [J]. Nucleic Acids Res, 2004, 32(14): 4411-4419.
  • 10Doudna JA, Cech TR. The chemical repertoire of natural ri bozymes[J]. Nature, 2002, 418(6894): 222-228.

二级参考文献11

  • 1Ruiz Gomez MJ, Souviron Rodriguez A, Martinez Morillo M. P-glycoprotein, a membrane pump that represents a barrier to chemotherapy in cancer patients. An Med Interna,2002,19:477-485.
  • 2Anthony V, Skach WR. Molecular mechanism of P-glycoprotein assembly into cellular membranes. Curr Protein Pept Sci, 2002,3:485-501.
  • 3Mathews DH, Sabina J, Zuker M, et al. Expanded Sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure .J Mol Biol, 1999,288: 911-940.
  • 4Hu K, Yao X. Methyl protogracillin (NSC-698792): the spectrum of cytotoxicity against 60 human cancer cell lines in the National Cancer Institute′s anticancer drug screen panel. Anticancer Drugs,2001,12:541-547.
  • 5Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem, 1987,162:156-161.
  • 6Fruehauf S, Breems DA, Knaan-shanzer S, et al. Frepuency analysis of multidrug resistency-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area froming cell assay and detection of vector-mediated p- glycoprotein ex
  • 7Masanek U, Stammler G, Volm M. Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P-glycoprotein 170 and PKC isoenzymes with antisense oligonucleotides. J Exp Ther Oncol, 2002,2:37-41.
  • 8Kavallaris M, Burkhart CA, Horwitz SB. Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol. Br J Cancer, 1999, 80:1020-1025.
  • 9Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature, 2002,418:222-228.
  • 10Kashani-Sabet M. Ribozyme therapeutics. J Investig Dermatol Symp Proc, 2002,7:76-78.

共引文献6

同被引文献39

引证文献3

二级引证文献18

国际检验医学杂志
2007年 第11期

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