摘要
目的观察海风藤对犬脑干缺血后脑干听觉诱发电位（ＢＡＥＰ）的影响。方法建立犬脑干缺血模型，给药组和对照组各２０只犬，分别于阻断基底动脉前３ｈ向十二指肠注入海风藤溶液（按０．３ｇ／ｋｇ）和等体积生理盐水，于缺血前和缺血后０．５、３、６和１２ｈ分别记录ＢＡＥＰ。结果给药组ＢＡＥＰ的Ⅰ、Ⅲ、Ⅴ波潜伏期和Ⅰ－Ⅲ、Ⅲ－Ⅴ、Ⅰ－Ⅴ波峰间期明显缩短。结论海风藤可改善犬脑干对缺血的耐受程度，减小半暗带的范围，减轻病变的程度。
Objectives To observe the effect of Piper Willichii on the changes of brainstem auditory evoked potentials (BAEP) in brainstem ischemia dogs. Methods A focal ischemia model of brainstem was established in 40 dogs. Piper Wiuichii pretreatment group(PW) and normal saline pretreatment group(NS) both have 20 dogs. PW(0.3g/kg) and same volume of normal saline were intraduodenally administered at 3 h before ischemia. BAEP were recorded dividedly at 0.5,3,6 and 12 h after brainstem ischemia. Results The results showed that the peak latencies for waves Ⅰ,Ⅲ,Ⅴ and the internal peak latencies for waves Ⅰ-Ⅲ,Ⅲ-Ⅴ,Ⅰ-Ⅴ of BEAP decreased significantly. Conclusions Piper Willichii can improve the tolerance of the dog on brainstem ischemia, decrease the range of ischemia penumbra and lighten the degree of pathological changes.
