睾丸激素受体4相关蛋白在非小细胞肺癌组织中的表达

Expression of TR4-associated protein in non-small cell lung cancer

目的:研究睾丸激素受体4相关蛋白(TR4-associated Protein,TRA16)在非小细胞肺癌组织(NSCLC)中的表达特点及其与肺癌发生、发展之间的相互关系。方法:以免疫组织化学方法结合组织芯片技术研究TRA16在各类NSCLC组织、肺良性病变组织及正常肺组织中的表达情况。结果:TRA16蛋白在NSCLC细胞浆和/或细胞核内具有较高的阳性表达率(88.64%),而在肺良性肿瘤及正常肺组织中均无阳性表达,表明TRA16在NSCLC组织中特异性高表达。在不同病理类型和不同分化程度的NSCLC中,TRA16的表达没有明显的差异。结论:首先发现TRA16在NSCLC组织中特异性高表达;TRA16在NSCLC组织中的异常表达,提示其可能与肿瘤的发生、发展相关,有可能成为一个新的潜在的与NSCLC相关的肿瘤标志物。

Objectives：To investigate the expression and significance of TR4-associated Protein（TRA16）in human non-small cell lung cancer（NSCLC）tissues.Methods：Immunohistochemistry（IHC）and tissue array were employed to investigate the expression of TRA16 in NSCLC cases of different pathological types,benign lung lesions and normal lung tissues.Results：The abundant expression of TRA16 was observed in nucleus and/or cytoplasm of NSCLC cells with a positive expression rate of 88.64%,whereas normal lung tissue and benign lung tumor rarely expressed TRA16 protein.The expression of TRA16 showed no apparent difference at pathotypes and differentiation levels.Conclusion：In this study we demonstrated an abnormal overexpression of TRA16 in NSCLC tissues.The unique expression pattern of TRA16 indicated its probable role in tumorigenesis and progression,supporting the development of TRA16 as a novel potential NSCLC marker.