焦虑、抑郁与乙肝病毒感染预后的癌基因研究

A oncogene study on anxiety and depression and prognosis of chronic HBV infection

目的探讨焦虑、抑郁不良情绪与慢性乙肝发展和转归的关系。方法采用ＬＳＡＢ免疫组化和ＥＬＩＳＡ方法，检测了５２例慢性ＨＢＶ感染者肝细胞Ｃ－ｅｂｂＢ－２Ｐ１８５癌基因蛋白及血清ＨＢｅＡｇ，同时进行了ＳＡＳ和ＳＤＳ调查，结果与国内常模对照。结果Ｃ－ｅｒｂＢ－２Ｐ１８５癌基因蛋白阳性患者ＳＡＳ和ＳＤＳ总标准分均值Ｘ分别为４４．２１０±６．１２和４９．１３±９．８７，分数升高与国内常模之间有显著差异，（Ｐ＜０．０１）。结论提示焦虑、抑郁情绪在慢性乙肝的发生发展中可能起重要作用。

Objective To explore the relationship between anxiety and depression and chronic hepatitis B.Methods Using immunohistochmica technigues and ELISA,We detected the expression of the protein product C erbB 2 P185 in hepatic tissue and HBeAg in the serum and measured the anxiety and depression by SAS、SDS in 52 cases with chronic HBV infection.Result The result showed that the means score of SAS and SDS were 44.21±6.12 and 49.13±9.87 in the positive patients with oncogene protein C erbB 2 P185 which were markedly higher than normal model. Conclusion Anxiety and depression may play an important roles in the occurence and development progress of chronic hepatitis B.