他汀类药物作用机制及其在卒中防治中的应用

The Acting Mechanisms of Statins and Their Application in the Prevention and Treatment of Stroke

在世界范围内卒中是最重要的致残病因之一。流行病学和临床研究显示,他汀类药物可显著降低缺血性卒中的发病率。除降脂效应外,他汀类药物还存在不依赖于降低胆固醇水平的其他许多作用机制。另外,他汀类药物可抑制蛛网膜下腔出血引起的脑血管痉挛。对于大多数个体来说,他汀类药物的安全性和耐受性良好。

Stroke is one of the most important causes of disability throughout the world. Epidemiological and clinical studies have demonstrated that statins significantly decrease the incidence of ischemic stroke. In addition to lipid-lowering effect, statins may also have a number of other acting mechanisms that are not dependent on reducing cholesterol levels. Moreover, statins inhibit cerebral vasospasm caused by subarachnoid hemorrhage. For most of the individuals, the safety and tolerability of statins are well.