卡托普利对冠状动脉急性闭塞后室性心律失常的影响

Effect of Captopril on Ventricular Arrhythmias after Acute Coronary Occlusion

目的:研究卡托普利(Captopril)对室性心律失常的治疗作用及其可能机制。方法:对17只兔心脏(对照组 n=8;干预组 n=9)行冠状动脉左室支中点完全结扎120分钟,观察两组心室纤颤(VF)发生率、心肌缺血面积、血浆去甲肾上腺素(NE)和血管紧张素Ⅱ(AⅡ)水平的变化。结果:干预组 VF 发生率明显低于对照组(11.1% vs 62.5%,P<0.05)。结论:卡托普利能抑制急性心肌梗塞早期 VF 的发生,这一作用与其降低血浆 NE、AⅡ浓度和减少心肌缺血面积有关。

Objective:To investigate the therapeutic effect of captopril on ventrieular arrhythmias and its potential mechanisms.Methods:Complete coronary ligation at the middle of left ventricular branch for 120 minutes was carried out in 17 rabbits(control group n=8;intervention group n=9).Incidence of ventricular fibrillation(VF),myocardial ischemie size,plasma levels of norepinephrine(NE)and an- giotensin Ⅱ(A Ⅱ)were observed.Results:The incidence of VF in intervention group was markedly lower than in control group(11.1% vs 62.5%,P<0.05).Conclusion:Captopril can inhibit the occurrence of VF in early stage of acute myocardial infarction and this effect may be related to the reduction in plas- ma concentrations of NE and A Ⅱ,as well as to the decrease in size of myocardial ischemia.