摘要
氧氟沙星、盐酸洛美沙星及氟罗沙星在２ｍｏｌ／Ｌ盐酸液中长时间加热回流，分离纯化后所得的降解物，经ＭＳ、１ＨＮＭＲ、１３ＣＮＭＲ、ＩＲ及ＵＶ测试与解析，并与原药比较，确证它们是原药的脱羧物。
Ofloxacin,lomefloxacin and freloxacin were degraded by refluxing in 2mol/L hydrochloric acid solution for a long period of time.The degradation products were isolated and identified by MS、UV、IR and NMR spectra as decarboxylates.
出处
《药物分析杂志》
CAS
CSCD
北大核心
1997年第2期89-92,共4页
Chinese Journal of Pharmaceutical Analysis
关键词
喹诺酮类药物
降解物
结构
quinolone drugs,degradation product,structure
