Ki-67在翼状胬肉中的表达及其临床意义

Expression of Ki-67 in Pterygium and It's Clinical Significance

目的研究Ki-67在翼状胬肉发生发展中的作用及其相关性,初步探讨其临床意义。方法应用免疫组化S-P法检测50例翼状胬肉组织和10例正常结膜组织中Ki-67的表达,并分析其与翼状胬肉临床病理参数间的关系。结果Ki-67阳性～强阳性表达36例,总阳性率为72%,正常结膜中只有1例阳性表达(占10%),差异具有统计学意义(P<0.05)。Ki-67在翼状胬肉组织的进展期、静止期和复发性病变组织的表达,差异具有统计学意义(P<0.05)。结论翼状胬肉组织上皮中Ki-67的异常表达提示翼状胬肉组织中细胞增殖调控异常,上皮细胞可能发生了转化,它在翼状胬肉的发生发展中可能起着重要的作用。

Objective To clinical significance. Methods study the role and relationship of Cryopreserved tissue specimens Ki-67 in pterygia and to evaluate the consisting of normal conjunctiva and pterygium were used to study the expression of Ki-67,using SP immunohistochemistry.The relationship between the expression and clinical pathological parameters were also analyzed. Results The positive rate of Ki-67 was 10% in 10 cases of normal tissues and 72% in 50 cases of pterygia, namely 36, the diference between them had markedly statistical significance （P〈0.05）. The staining intensity of Ki-67 in pterygia was significantly associated with the clinicopathologic stage and recurrence P〈0.05）. Conclusion The higher expression of Ki-67 in the epithelium of the pterygium may indicate abnormal regulation of proliferation. The epithelium has acquired transformation and may play an important role in the development of pterygium.