肾血管性高血压大鼠血清中血管性假血友病因子和高敏C反应蛋白动态变化

The Dynamic Changes of Serum Von Willebrand Factor and High Sensitivity C-Reactive Protein in Renovascular Hypertensive Rats

目的研究易卒中型肾血管性高血压大鼠血清中血管性假血友病因子和高敏C反应蛋白在高血压病程中的动态变化,并探讨血管性假血友病因子和高敏C反应蛋白在高血压脑动脉粥样硬化及脑卒中发生、发展中的作用。方法双肾双夹法复制肾血管性高血压大鼠模型,酶联免疫吸附试验检测肾血管性高血压大鼠血清中血管性假血友病因子和高敏C反应蛋白的含量,并分别与对照组和假手术组比较。结果术后第4、8、12周末,高血压组血清血管性假血友病因子和高敏C反应蛋白含量均较对照组和假手术组显著升高,且随造模时间延长,不同阶段高血压组血清血管性假血友病因子和高敏C反应蛋白含量也随之升高。结论随着高血压病情进展,血清中血管性假血友病因子含量和高敏C反应蛋白含量也同步升高,两者均参与高血压动脉粥样硬化的发生、发展。高血压时血清中增高的血管性假血友病因子和高敏C反应蛋白均可能是其并发缺血性脑卒中的危险因素。

Aim To study dynamic changes of serum von Willebrand factor （vWF） and high sensitivity C-reactive protein （hs-CRP） in renovascular hypertensive rats, and to investigate the effect of vWF and hs-CRP in the deployment of atherosclerosis （As） andstmke. Methods vWFandhs-CRPwere measured with enzyme linked immunoabsorbent assay （ELISA）, the results were compared with the control group and sham-opetated group. Results At the end of 4,8,12 weeks after the operation,the concenrations of serum vWF and hs-CRP were significantly increased compared with the control group and sham-operated group; the blood pressure were increasing in the hypertensive group after the operation, and the coneenrations of serum vWF and hs-CRP were increasing simultaneously. Conclusion When tire blood pressure were increasing, the concenrations of serum vWF and hs-CRP were increasing simultaneously; vWF and hs-CRP played vital roles in As. The high coneenrations of serum vWF and hs-CRP might be the risk factors to ischemic stroke.