摘要
目的评价立体定向放射治疗颅内转移性黑色素瘤的临床效果。方法回顾性分析我院于1998年5月至2005年11月间对23例颅内转移性黑色素瘤患者28个病灶进行立体定向放射治疗,男性17例,女性6例,年龄45～80岁,中位年龄61岁。肿瘤最大径0.8～3.8cm(平均2.5cm),剂量为(5～9)Gy×(3～7)次(80%等剂量曲线)(平均32Gy)。结果治疗后3～12个月评价治疗效果,经3～24个月(平均11.4个月)的随访,28灶黑色素瘤中完全消失为5灶(17.9%),部分消失为20灶(71.4%)。临床症状减轻为20例(87.0%),3例无效(13.0%)。死亡率为16/23(69.6%)。结论立体定向放射治疗转移性颅内黑色素瘤可以提高患者的生活质量,但病情发展快,预后差,治疗主要采用综合疗法。
Objective To evaluate the clinical effect of stereotactic radiotherapy for intracranial metastatic melanoma. Methods Twenty-eight tumor targets of twenty-three patients with intracranial metastatic melanoma were treated between May 1998 and November 2005 ,there were 17 males and 6 females, mean age 61yr （45-80yr）.The diameter of the lesions ranged 0.8-3.8cm （mean 2.5cm）.The patients were given a dose of（ 5-9）Gy×（ 3-7 ）prescribed to the 80% isodose（mean 32Gy）.Results The therapeutic efficacy was evaluated 3-12 months after stereotactic conformal radiotherapy. Through the follow-up period of 3 -24 months （11.4）, 5 of total 28 melanoma completely disappeared （76.9%）,20 partially relieved （71.4%）.Clinical symptoms were relieved after treatment in 20 patients （87.0%） and been ineffective in 3 patients （13.0%）.The mortality was 16/23 （69.6%）. Conclusious This treatment have played a importment role in improving patients＇ living quatality, but intracranial metastatic melanoma was characterized as having rapid development and poor prognosis.Combined treatment should be adopted.
