高同型半胱氨酸血症与脑卒中的关系探讨

Relationship between Hyperhomocysteinemia and Stroke

目的探讨高同型半胱氨酸(Hcy)血症与脑卒中的关系,进而为脑梗死的防治提供新的理论依据。方法测定169例脑卒中患者其中脑梗死103例、短暂脑缺血发作(TIA)52例、脑出血14例和60例健康对照者空腹血浆Hcy水平,以此结果将患者分为高Hcy组和非高Hcy组。结果脑梗死组、TIA组和脑出血组血浆水平分别为男(24.1±8.7)μmol/L、女(16.4±8.9)μmol/L,显著高于对照组的男(13.8±2.8)μmol/L、女(11.3±2.7)μmol/L,P<0.01。结论经Logistic回归分析Hcy升高是脑卒中的独立危险因素(P<0.01),与卒中后再发有直接危险因素。

Objective To explore the possible effect of the plasma homocysteine level on the risk of cerebral infarction, so as to find a new theoretical evidence for the therap and the prophylaxis of cerebral infarction. Methods We examined the free plasm total homocysteine （Hcy） of 169 patients with cerebral infarction,including 103 patients with acute cerebral infarction （CI） ,52 patients with transient ischemic attack（TIA） , 14 patients with cerebral hemorrhage（CH）. Based on the level of plasma total Hcy in 60 healthy controls,patients were divided into hyperhomocysteinemia （Hhcy） group and no hyparhomocysteinemia （Nhhey） group, Results Mean plasma Hcy was significantly higher in the all three groups （group CI, group TIA and group CH） compa- ring with normal control, By stepwise Logistic analysis,we found that the increased Hcy was a independent risk factor of the re- curred stroke（P 〈 0.01 ）, Conclusions Hhcy is closely correlated with the recurrent cerebral infarction after previous ischemic stroke.