560例泌尿生殖道支原体感染及耐药性分析

Infection Status and Drug-susceptibility Analysis of 560 Mycoplasma Strains Isolated from Genitourinary Tract

目的了解泌尿生殖道支原体感染的现状及耐药性,为临床合理用药提供依据。方法对2005-2006年就诊的可疑非淋菌性尿道炎(宫颈炎)患者进行支原体的培养及药敏检测,分析。结果1160例疑似非淋菌性尿道炎(NGU)患者中,560例支原体培养阳性,阳性率为48.28%,其中解脲脲支原体(Uu)540例占96.43%;人支原体(Mh)12例占2.14%;Uu+Mh阳性者8例占1.42%。药敏结果表明:支原体对12种抗菌药物耐药率较高的是诺氟沙星(64.11%)、氧氟沙星(45.00%)、红霉素(40.54%);耐药率较低的药物为交沙霉素(1.07%)、强力霉素(3.57%)、美满霉素(3.57%),多重耐药率为42.14%(236/560)。结论泌尿生殖道支原体感染主要以Uu发病率最高,多重耐药率较高,对支原体感染治疗应根据药敏结果合理使用抗生素。

Objective To investigate the infection status and drug resistance of Mycoplasma strains isolated from genitourinary tract and provide strategies for treatment. Methods The results of U urealyticum culture and drug sensitivity tests were explored from 2005 to 2006. Results The mycoplasma infection ratio was 48.48% with Ureaplasma urealyticum （Uu） 96.43 %, Mycoplas- ma hominis（Mh） 2.14% and mixed infection 1.42% ,respectively. The drug susceptibility test showed that drug resistance ratios were as follows： to Norfloxacin （64. 11% ）, ofloxacin （45.00%）, erythromycin （40.54%）, josamycin 1. 07%, doxycycline （3.57%） and minocyclln （3.57%） ,the rate of multiple-resistance 42.14% （236/560）. Conclusions Mycoplasma infection in genitourinary tract is mainly due to Uu infection. It have higher multiple-antibiotic resistance. We should rationally choose and use antibiotics according to the drug susceptibility.