摘要
成体哺乳动物中枢神经系统(CNS)髓磷脂可影响神经的可塑性并抑制神经纤维的再生。Nogo-A被认为是中枢神经系统中抑制轴突生长最关键的一种髓磷脂抑制分子。在脊髓损伤(SCI)动物模型中,抑制Nogo-A的活性可明显促进轴突再生及功能改善。Nogo-A及其信号转导机制的研究日益成为SCI修复过程中的研究热点;Nogo-A及其信号转导分子特别是Nogo-66受体(NgR)、p75神经营养素受体(p75NTR)和LINGO-1成为损伤后促进轴突再生、抑制生长锥塌陷的主要治疗靶点。抑制Nogo-A及其受体NgR/p75NTR/LINGO-1可能有助于SCI的修复,促进患者功能的恢复。
Myelin of the adult mammalian central nervous system （CNS） has been attributed to affect nerve structural plasticity and suppress regeneration of nerve fibers. Nogo-A is possibly the best characterized of a variety of neurite growth inhibitors in CNS myelin. Neutralizing its activity results in improved axon regrowth and functional recovery in experimental spinal cord injury （SCI） models of animals. Nogo-A and its receptors, especially Nogo-66 receptor （NgR）, p75 neurotrophin receptor （p75NTR）, and LIN- GO-1 increasingly become the hot spot in the study of SCI repair, and have become the major targets for therapeutic intervention to promote axon regeneration after SCI. Inhibition of Nogo-A and its receptors NgR/p75NTR/LINGO-1 may be promote the regeneration of axon and maximize functional recovery after SCI.
出处
《中国康复理论与实践》
CSCD
2007年第11期1008-1010,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金资助项目(No.30600665)
第三军医大学青年科研基金资助项目(No.06XG048)
