术前应用氟比洛芬酯对脊髓损伤患者术后镇痛的效果

Postoperative Analgesic Effects of Flurbiprofen Axetil Applied Preoperatively on Patients with Spinal Cord Injury

目的观察术前使用氟比洛芬酯注射液对脊髓损伤患者手术后镇痛的效果。方法46例全麻下接受脊柱手术的脊髓损伤患者随机分为氟比洛芬酯注射液组(F组)和对照组(C组),每组23例。切皮前,F组静脉注入氟比洛芬酯注射液1mg/kg;C组注入生理盐水1ml/kg。观察两组患者术后2h、4h、8h、24h和48h的疼痛视觉模拟评分(VAS)及术后48h内不良反应的发生情况。结果F组术后2h、4h、8h和24h的VAS评分低于C组(P<0.05);但术后48h与C组的VAS评分差异无显著性意义(P>0.05);两组的术后48h内不良反应的发生率差异无显著性意义(P>0.05)。结论术前使用氟比洛芬酯注射液能有效减少脊髓损伤患者在脊柱手术后的疼痛,并且不增加不良反应的发生率。

Objective To observe the post-operative analgesic effect of flurbiprofen Axetil applied preoperatively on patients with spinal cord injury （SCI）. Methods 46 SCI patients undergoing spine surgery under general anesthesia were randomly divided into the flurbiprofen axetil group （group F） and control group （group C） with 23 cases in each group. Before cutting skin, flurb^profen axetil （1 mg/kg） was injected intravenously in the group F, and normal saline （1 ml/kg） was infected intravenously in the group C. The scores of Visual Analogue Scale （VAS） for pain at postoperative 2, 4, 8, 24,and 48 hours, and the incidence of side effects within 48 hours after operation were recorded. Results VAS scores at the time of 2, 4, 8 ,and 24 h after operation in the group F were significantly lower than that in the group C （ P 〈0.05）. But VAS scores of two groups at 48 h were not significantly different （ P 〉0. 05）. The incidences of side effects of two groups were also not significantly different （ P 〉0. 05）. Conclusion Flurbiprofen axetil applied preoperatively can release pain of SCI patients after spine surgery, and does not increase the incidence of side effects.