583例住院患者使用头孢三代抗菌药物合理性分析

Analysis on Rational Use of Cephalosporins in 583 Cases of a Large General Hospital

目的探讨大型综合型医院抗菌药物使用的合理性。方法对2006年11月20-26日583例住院患者使用5种最常用抗菌药物的临床资料进行分析。结果抗菌药物使用前5位的药物均为头孢三代,分别为头孢哌酮/他唑巴坦(凯斯)、氟氧头孢(氟吗宁)、头孢哌酮/他唑巴坦(凯舒特)、头孢匹胺(希柏澳)、头孢哌酮/他唑巴坦(仙必他);药物应用的次数基本符合药物代谢动力学特征;还有相当部分的患者予以长程单一抗菌药物治疗,最长的连续应用长达22 d;药物应用剂量偏大占19.9%。结论抗菌药物应用基本合理,但应进一步加强合理用药培训和教育。

OBJECTIVE To study the rational use of antibiotics in a comprehensive general hospital. METHODS The clinical data of 583 cases used the five kinds of most frequently antibiotics during Nov 20-26, 2006 in a comprehensive general hospital were collected and analyzed. RESULTS The total five kinds of most frequently antibiotics used in this hospital were the third generation of cephalosporins, cefoperazone/tazobactam （Kaisi）, flomoxef （Fuomaning）, cefoperazone/tazobactam （Kaishute）, cefpiramide （Xibaiao） and cefoperazone/tazobactam （Xianbita）. The daily frequency of these antibiotics was rational to the drug metabolic dynamics characteristics. Some patients received the long time therapy of antibiotic, the longest one was 22 days. The frequency of over- doses in these patients was 19.9 %. CONCLUSIONS Antibiotics use is apparently rational in this hospital and the training and education for drug use should be enhanced in the future.