摘要
目的研究鼻咽癌组织中间质微血管密度分布特点及与肿瘤转移的关系。方法应用免疫组织化学Elivision Plus二步法,检测50例鼻咽癌、15例炎性鼻咽黏膜组织间质微血管密度(MVD)的分布,并检测切片上MMP2的表达。结果鼻咽癌组织MVD(21.92±7.80)明显高于炎性鼻咽黏膜组织(9.23±1.84),两者之间差异有统计学意义(P<0.01);此外,鼻咽癌MVD与临床T分期、淋巴结转移密切相关(P<0.01)。结论鼻咽癌组织中的MVD与鼻咽癌的浸润转移密切相关。MVD有可能成为判定鼻咽癌生物学行为和预后的重要指标。
Objective To study clinicopathologic significance of microvessel density（MVD） and the expression of CD34 in nasopharyngeal carcinoma. Methods Using Elivision Plus immunohistochemistry method. 50 cases of nasopharyngeal carcinoma and 15 cases of inflammation nasopharyngeal tissues were stained with CD34. Results In comparison with inflammation nasopharyngeal tissues MVD （9.23± 1.84 ）, the MVD in nasopharyngeal carcinoma （21.92 ± 7.80） was significantly higher（ P 〈 0. 01 ）. In addition, the MVD was correlated with clinical stage and lymph node metastasis（P 〈 0.01 ）, but there was no relationship with age, tumor size.Conclusion MVD may be very important indicators to determine biological behavior and prognosis of nasopharyngeal carcinoma.
出处
《中国基层医药》
CAS
2007年第10期1607-1609,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
广东省深圳市科技计划项目(200304287)
关键词
鼻咽肿瘤
新生血管化
免疫组织化学
Nasopharyngeal neoplasms
Neovascularization
Immunohistochemistry
