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商陆抗病毒蛋白抗病毒作用研究进展 被引量：1

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摘要 美洲商陆抗病毒蛋白（pokeweed antiviral protein，PAP）是从美洲商陆属植物Phytolacca acinosa的不同生长阶段或不同组织中分离和纯化出来的一类具有酶功能的核糖体单链失活蛋白（ribosome-inactivating proteins，RIP）。由于PAP具有特异的细胞毒特性，对细胞蛋白质合成的抑制作用以及广谱的抗病毒生物活性，而受到广大研究者的日益关注，本文就PAP抗病毒作用的有关研究综述如下。
作者 陈瑞烈 林少锐 李忆璇 郑晓丹
机构地区 汕头市中心医院中山大学附属汕头医院感染科
出处 《中国基层医药》 CAS 2007年第10期1733-1734,共2页 Chinese Journal of Primary Medicine and Pharmacy
基金 广东省汕头市科技局基金(汕府科[2006]82号)
关键词 美洲商陆抗病毒蛋白 抗病毒作用 PROTEIN 商陆属植物 蛋白质合成 失活蛋白 生长阶段 生物活性
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献28

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二级参考文献20

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共引文献8

同被引文献18

  • 1田野苹,郑玲莉,周正芳.P物质对刀豆素A和美洲商陆诱导小鼠脾细胞产生γ干扰素的调节作用[J].第二军医大学学报,1990,11(1):19-22. 被引量：2
  • 2蒋妮,缪剑华,谢保令.商陆等6种药用植物粗提物对扶芳藤稠李巢蛾的杀虫活性[J].中国农学通报,2006,22(10):297-299. 被引量：7
  • 3孙文基,姚烁,赖道力,等.商陆总苷元的制备及在镇咳祛痰药物中的应用.中国实验方剂学,2006:11.
  • 4Endo YK, Fsurugi, Lambert JM. The site of action of six uiticrent ribosome-inactivating proteins from plants on cukaryotic ribosomes: the RNA N-glycosidase activity of the proteins. Biochem Biophys Res Commun, 1988,150 : 1032-1036.
  • 5Chen ZC, WhiteRF, Antoniw JF, et al. Effect of pokeweed antivi- ral protein(PAP) on the infection of plant viruses. Plant Pathol, 1991,40:612.
  • 6Tomlinson JA, Walker VM, Flewett TM, et al. The inhibition of in-fection of cucumber mosaic virus and influenza virus by extracts from Phytolacea Americana. J Gen Virol, 1974,22:225-232.
  • 7Aron GM, Irvin JD. Inhibition of herpes simplex virus multiplica- tion by the pokeweed antiviral protein. Antimierob Agents Che- mother, 1980,17 : 1032-1033.
  • 8Teltow G J, Irvin JD, Aron GM, et al. Inhibition of herpes simplex virus DNA synthesis by pokeweed antiviral protein. Antimicrob A- gents Chemother, 1983,23 (3) :390-396.
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  • 10Zarling JM, Moran PA, Haffar O, et al. Inhibition of HIV replica- tion by pokeweed antiviral protein targeted to CD + 4 cells by mon- oclonal antibodies. Nature, 1990,347:92-95.

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二级引证文献8

中国基层医药
2007年 第10期

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