子痫前期血清脂联素反常升高与瘦素水平改变的相关性

Paradoxical devation of senna adiponectin and its relationship with the level of serum leptin in preeclampsia

目的探讨血清脂联素、瘦素和可溶性瘦素受体水平在子痫前期患者中的变化及其意义。方法采用酶联免疫吸附试验方法检测38例子痫前期患者和42例正常妊娠(对照组)血清脂联素、瘦素和可溶性瘦素受体水平,并计算游离瘦素指数值(瘦素/可溶性瘦素受体)。结果子痫前期患者血清脂联素、瘦素和游离瘦素指数分别为1691.7μg/ml、37.5 ng/ml和0.95,明显高于对照组(分别为689.4μg/ml、19.3ng/ml和0.49),但两组别间可溶性瘦素受体水平则未见明显差异(分别为35.0ng/ml和42.2 ng/ml)。在脂联素和瘦素、可溶性瘦素受体及游离瘦素水平间并未见明显相关,子痫前期患者脂联素、瘦素和游离瘦素的ROC曲线下面积均低于0.5。结论子痫前期患者血清脂联素水平存在明显的反常升高,瘦素的生物利用度也明显提高,可能与子痫前期的发生发展有关。

Objective To investiagte the serum adiponectin concentration in preeclampsia and its relationship with serum leptin and soluble leptin receptor levels. Method The level of adiponectin, leptin and soluble leptin receptor in serum were measured by enzyme-linked immunosorbent assay （ELISA） in 38 patients with preeclampsia and 42 patients as control. The relationship of free leptin index （leptin/soluble leptin receptor） to preeclampsia was analyzed. Results There were no significant differences in maternal age, gestational age and body mass index （BMI） between two groups. But the gestational age and birth weight were significantly lower in preeclampsia than in control. The patients with preeclampsia had significantly higher levels of serum adiponectin, leptin and free leptin index （ 1691.7 μg/ml, 37.5 ng/ml and 0.95 respectively） than the control （689.4 μg/ml, 19.3 ng/ml and 0.49, respectively）. But there was no significant difference in serum level of soluble leptin receptor between the groups （35.0 ng/ml vs 42.2 ng/ml）. Serum adiponectin was not significantly correlated with the level of leptin, soluble leptin receptor and free leptin index. Area of serum adiponectin, leptin and free leptin index in preeclampsia under the ROC curve were less than 0.5. Conclusions The patients with preeclampsia have paradoxical higher serum levels of adiponectin and more bioavailability of leptin, suggesting these may be important factors of this complication.