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核因子κB抑制因子α基因多态性与胃癌的相关性研究 被引量:2

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摘要 目的研究核因子κB抑制因子“(NFκBIA)基因多态性及其与胃癌的相关性。方法采用PCR-RFLP方法检测171例胃癌患者(胃癌组)和152例正常对照者(对照组)的NFκBIA基因多态性分布。结果胃癌组和正常对照组NFκBIA基因型分布符合Hardy-Weinberg平衡。胃癌组NFκBIAG/G基因型(34%)高于正常对照组(25%),而A/A基因型(13%)明显低于正常对照组(32%),两组比较差异有统计学意义(均P〈0.05)。等位基因G与胃癌呈正相关(χ^2=11.871,P=0.0006,OR=1.751,95%CI1.281~2.394),而等位基因A与胃癌呈负相关(χ^2=18.886,P=0.0001,OR=0.487,95%CI0.354~0.671)。结论NFκBIA基因多态性与胃癌有显著相关性。
出处 《中华胃肠外科杂志》 CAS 2007年第6期585-586,共2页 Chinese Journal of Gastrointestinal Surgery
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