摘要
选择生物相容性好,可生物降解的壳聚糖为药物载体,并通过体外释放试验和体外抗菌试验,从载体的自身结构和释药过程的两个方面,对其结构进行了测定和分析。结果表明,所合成的利福平壳聚糖体系;具有一定缓释性能,符合临床使用要求,可作为新型缓释药物临床应用。
The biological compatible and biodegradated chtosan was chosed as a medical carrier.The structures and degrodation behaviours of both chitosan and REP chitosan have been determined by a serious of medical disolvation and antibiosis contrasive experiments out of body.The results show that ouun syrthefic REPchitosan is a new kind of slow release medicine that may be used for clinic in the near future.