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血管内皮细胞骨架及其与心血管疾病的关系 被引量:6

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摘要 内皮细胞骨架由微丝、微管和中间纤维组成,是细胞形态维持、细胞迁移、物质运输和跨膜信息传递的重要结构基础。已发现内皮细胞骨架重排与心血管疾病的发生、发展过程有密切联系,故阐明内皮细胞骨架与心血管疾病的关系无疑对心血管疾病的防治有重要意义。本文拟从内皮细胞骨架的分布、结构特点、信号传导途径及其与心血管疾病的关系等方面,对目前的研究现状进行综述。
作者 彭红艳 常青
出处 《中国循环杂志》 CSCD 北大核心 2007年第5期394-396,共3页 Chinese Circulation Journal
基金 国家自然科学基金资助项目(30240076)
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参考文献15

  • 1Goode BL,Drubin DG,Barnes G.Functional cooperation between the microtubule and actin cytoskeletons.Current Opinion in Cell Biology,2000,12:63-71.
  • 2Wojciak-Stothard B,Ridley AJ.Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases.The Journal of Cell Biology,2003,16:429-439.
  • 3韩雅玲,张效林,康建,闫承慧,于海波,李少华,王士雯.RhoA介导凝血酶或脂多糖诱导内皮细胞株单层通透性增高[J].基础医学与临床,2006,26(4):386-391. 被引量:4
  • 4Desai TR,Leeper NJ,Hynes KL,et al.Interleukin-6 causes endothelial barrier dysfuntion via the protein kinase C pathway.Journal of Surgical Research,2002,104:118-123.
  • 5吴杰裕,肖能坎,黄巧冰,黄绪亮,石胜军,肖添有,刘洪.蛋白激酶对内毒素休克后内皮细胞骨架的作用[J].中华外科杂志,2003,4(3):193-196. 被引量:2
  • 6陈玉成,梁玉佳,刘瑞,黄明慧,曾智.氧化低密度脂蛋白对血管内皮细胞骨架的损伤及其机制[J].心血管康复医学杂志,2004,13(4):320-321. 被引量:41
  • 7Kreis S,Schfnfeld H J,Melchior C,et al.The intermediate filament protein vimentin binds specifically to a recombinant integrin a2/h1 cytoplasmic tail complexand co-localizes with native a2/h1 in endothelial cell focal adhesions.Experimental Cell Research,2005,305:110-121.
  • 8Shay-Salit A,Shushy M,Wolfovitz E,et al.VEGF receptor-2 and the adherens junction as a mechanical transducer in vascular endothelial cells.Proceedings of the National Academy of Sciences of the Unite States of America,2002,99:9462-9467.
  • 9Keezer SM,IVIE SE,Krutzsch HC,et al.Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin.Cancer research,2003,63:6405-6412.
  • 10Charles CD,Ide L,Davis ME,et al.Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth.Circulation Research,2004,95:488-495.

二级参考文献29

  • 1杜冠华.血管内皮细胞损伤机制及保护药物的研究[J].基础医学与临床,2004,24(3):258-263. 被引量:43
  • 2[1]Ross R. The pathogensis of atherosclerosia a perspective for the 1900s [J]. Nature, 1993, 362, 80.
  • 3[2]Lee JS, Gotlieb AI. Understanding the role of the cytoskeleton in the complex regulation of the endothelial repair [J]. Histology & Histopathology, 2003, 18 (3): 879-887.
  • 4[3]Kuhne W, Besselmann M, Noll T, et al. Disintegration of cytoskeletal structure of actin filaments in energy-depleted endothelial cellas [J]. Am J Physiol, 1993, 263 (2): H1599.
  • 5[4]Park JH, Okayama N, Gute D, et al. Hypoxia/alycemia increses endothelial permeability: role of second messengers and cytoskeleton [J]. Am J physiol, 1999, 277 (6pt): C1066-1074.
  • 6[5]Daniel B, Jeanne M, Barbara C, et al. Mechanism of endothelial cell shape change in oxidant injury [J]. J Surg Res, 1989 (46):339- 349.
  • 7[7]Mabile L, Fitoussi G, Periquet B, et al. α-Tocopherol and trolox block the early intracellular events (TABRS and calcium rises)elecited oxidiaed low density lipoproteins in cultured endothelial cells [J]. Free Radical Biology & medcine, 1995, 19 (2): 177.
  • 8Lu Q,Harrington EO,Hai CM,et al.Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability:involvement of RhoA carboxyl methylation[J].Circ Res,2004,94 (3):306-315.
  • 9Essler M,Retzer M,Bauer M,et al.Mildly oxidized low density lipoprotein induced contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosatase[J].J Biol Chem,1999,274 (43):30361-30364.
  • 10Van Nieuw Amerongen GP,Vermeer MA,Negre-Aminou P,et al.Simvastatin improves disturbed endothelial barrier function[J].Circulation,2000,102(23):2803-2809.

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