p53基因蛋白在大肠腺瘤中的表达及其与细胞增殖的关系

EXPRESSION OF p53 PROTEIN IN COLORECTAL ADENOMAS AND ITS RELATIONSHIP TO CELLULAR DYSPLASIA

用免疫组化及双标记法研究ｐ５３蛋白在大肠腺瘤中的表达，以及ｐ５３蛋白与增殖细胞核抗原、核仁区嗜银蛋白的关系。结果表明，ｐ５３蛋白表达率及强度随腺瘤不典型增生程度和体积增加而增加。ｐ５３蛋白阳性者增殖细胞核抗原标记指数，细胞核仁区嗜银蛋白平均银染颗粒数明显高于ｐ５３蛋白阴性者，提示ｐ５３蛋白过度表达在大肠腺瘤发生、发展及癌变过程中起重要作用，ｐ５３蛋白可能有促进细胞增殖的作用。

The expression of p53 protein in colorectal adenomas and its relationship to the clinicopathologic characteristics,cellular proliferation indexes (PCNA,AgNORs)were investigated using immunohistochemical and histochemical immunohistochemical double staining method.The results showed the positive rate and degree of staining enhanced with the increase of dysplasia and sizes of the adenomas.PCNA labeling index and AgNORs count were significantly higher in the adenomas with p53 protein expression than that without p53 protein expression. The results suggested that the over expression of p53 protein might play an important role in the development and malignant transversion of the adenomas.p53 protein may promote cellular proliferation.