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Andrographolide inhibits NF-KB activation and attenuates neointimal hyperplasia in arterial restenosis 被引量：11

Andrographolide inhibits NF-KB activation and attenuates neointimal hyperplasia in arterial restenosis
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作者 YuJiu Wang Jin Tao Wang QuanXin Fan Jian Guo Geng
机构地区 Department of Cardiac Surgery Laboratory of Molecular Cell Biology
出处 《Cell Research》 SCIE CAS CSCD 2007年第11期933-941,共9页 细胞研究（英文版）
基金 This work was supported by grants from the National Natural Science Foundation of China （30370694, 30421005, 30623003, 30400245 and 30630036）, the Ministry of Science and Technology of China （2002CB513006, 2006CB943902 and 2006AA02Z 169）, the Chinese Acad- emy of Sciences （KSCX2-YW-R-67 and KJCX2-YW-H08） and the Shanghai Municipal Commission for Science and Technology （04JC14078, 06DZ22032, 055407035 and 058014578）.
关键词 NF-kB转录因子 穿心莲内酯 动脉狭窄 内皮增生 NF-kB transcription factors, andrographolide, neointimal hyperplasia, arterial restenosis, TF, E-selectin, VCAM-I
分类号 R543 [医药卫生—心血管疾病]
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参考文献30

  • 1Schmitz ML, Mattioli I, Buss H, Kracht M. NF-κB: a multifaceted transcription factor regulated at several levels. Chembiochem 2004; 5:1348-1358.
  • 2Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002; 2:725-734.
  • 3Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA. Possible new role for NF-kappaB in the resolution of inflammation. Nat Med 2001; 7:1291-1297.
  • 4Yamamoto Y, Gaynor RiB. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest 2001; 107:135-142.
  • 5Cercek B, Yamashita M, Dimayuga P, et al. Nuclear factor-kappaB activity and arterial response to balloon injury. Atherosclerosis 1997; 131:59-66.
  • 6Lindner V. The NF-kappaB and IkappaB system in injured arteries. Pathobiology 1998; 66:311-320.
  • 7Landry DB, Couper LL, Bryant SR, Lindner V. Activation of the NF-kappa B and Ikappa B system in smooth muscle cells after rat arterial injury. Induction of vascular cell adhesion molecule- 1 and monocyte chemoattractant protein-1. Am J Pathol 1997; 151:1085-1095.
  • 8Squadrito F, Deodato B, Bova A, et al. Crucial role of nuclear factor-kappaB in neointimal hyperplasia of the mouse carotid artery after interruption of blood flow. Atherosclerosis 2003; 166:233-242.
  • 9Xia YF, Ye BQ, Li YD, et al. Andrographolide attenuates inflammation by inhibition ofNF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol 2004; 173:4207-4217.
  • 10Geng JG, Bevilacqua ME Moore KL, et al. Rapid neutrophil adhesion to activated endothelium mediated by GMP- 140. Nature 1990, 343:757-760.

同被引文献57

引证文献11

二级引证文献36

Cell Research
2007年 第11期

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